Noel Southall: search on Z-Library

Fundraising September 15, 2024 – October 1, 2024 About fundraising

The world's largest scientific articles store. 70,000,000+ articles for free.

Fundraising September 15, 2024 – October 1, 2024

Z-Library is one of the largest online libraries in the world that contains over 17,000,000 books and 84,837,000 articles. We aim to make literature accessible to everyone. Today (September 15, 2024) we've started additional fundraising to project maintenance and development.

Also UNLIMITED downloads (for 31 days after the day of making donation) are available for ALL contributors who will donate during the fundraising period till October 1, 2024.

About fundraisingRead more

Make a donation

1

Critical Assessment of Artificial Intelligence Methods for Prediction of hERG Channel Inhibition in the âBig Dataâ Era

Siramshetty, Vishal B., Nguyen, Dac-Trung, Martinez, Natalia J., Southall, Noel T., Simeonov, Anton, Zakharov, Alexey V.

Journal:

Journal of Chemical Information and Modeling

Year:

2020

File:

PDF, 3.97 MB

2020

2

A high throughput glucocerebrosidase assay using the natural substrate glucosylceramide

Omid Motabar, Ehud Goldin, William Leister, Ke Liu, Noel Southall, Wenwei Huang, Juan J. Marugan, Ellen Sidransky, Wei Zheng

Journal:

Analytical and Bioanalytical Chemistry

Year:

2012

Language:

english

File:

PDF, 350 KB

english, 2012

3

Fluorescence Spectroscopic Profiling of Compound Libraries

Simeonov, Anton, Jadhav, Ajit, Thomas, Craig J., Wang, Yuhong, Huang, Ruili, Southall, Noel T., Shinn, Paul, Smith, Jeremy, Austin, Christopher P., Auld, Douglas S.

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1.55 MB

english, 2008

4

How Ions Affect the Structure of Water

Hribar, Barbara, Southall, Noel T., Vlachy, Vojko, Dill, Ken A.

Journal:

Journal of the American Chemical Society

Year:

2002

Language:

english

File:

PDF, 652 KB

english, 2002

5

A View of the Hydrophobic Effect

Southall, Noel T., Dill, Ken A., Haymet, A. D. J.

Journal:

Journal of Physical Chemistry B

Year:

2002

Language:

english

File:

PDF, 430 KB

english, 2002

6

A Basis for Reduced Chemical Library Inhibition of Firefly Luciferase Obtained from Directed Evolution

Auld, Douglas S., Zhang, Ya-Qin, Southall, Noel T., Rai, Ganesha, Landsman, Marc, MacLure, Jennifer, Langevin, Daniel, Thomas, Craig J., Austin, Christopher P., Inglese, James

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 386 KB

english, 2009

7

Discovery, Optimization, and Characterization of Novel D 2 Dopamine Receptor Selective Antagonists

Xiao, Jingbo, Free, R. Benjamin, Barnaeva, Elena, Conroy, Jennie L., Doyle, Trevor, Miller, Brittney, Bryant-Genevier, Marthe, Taylor, Mercedes K., Hu, Xin, Dulcey, Andrés E., Southall, Noel, Ferrer,

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.29 MB

english, 2014

8

A novel quantitative high-throughput screen identifies drugs that both activate SUMO conjugation via the inhibition of microRNAs 182 and 183 and facilitate neuroprotection in a model of oxygen and glucose deprivation

Bernstock, Joshua D, Lee, Yang-ja, Peruzzotti-Jametti, Luca, Southall, Noel, Johnson, Kory R, Maric, Dragan, Volpe, Giulio, Kouznetsova, Jennifer, Zheng, Wei, Pluchino, Stefano, Hallenbeck, John M

Journal:

Journal of Cerebral Blood Flow and Metabolism

Year:

2015

Language:

english

File:

PDF, 8.54 MB

english, 2015

9

Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis

Frankowski, Kevin J., Wang, Chen, Patnaik, Samarjit, Schoenen, Frank J., Southall, Noel, Li, Dandan, Teper, Yaroslav, Sun, Wei, Kandela, Irawati, Hu, Deqing, Dextras, Christopher, Knotts, Zachary, Bia

Journal:

Science Translational Medicine

Year:

2018

Language:

english

File:

PDF, 1.77 MB

english, 2018

10

The use or generation of biomedical data and existing medicines to discover and establish new treatments for patients with rare diseases – recommendations of the IRDiRC Data Mining and Repurposing Task Force

Southall, Noel T, Natarajan, Madhusudan, Lau, Lilian Pek Lian, Jonker, Anneliene Hechtelt, Deprez, Benoît, Guilliams, Tim, Hunter, Lawrence, Rademaker, Carin MA, Hivert, Virginie, Ardigò, Diego

Journal:

Orphanet Journal of Rare Diseases

Year:

2019

File:

PDF, 569 KB

2019

11

Evaluating kratom alkaloids using PHASE

Ellis, Christopher R., Racz, Rebecca, Kruhlak, Naomi L., Kim, Marlene T., Zakharov, Alexey V., Southall, Noel, Hawkins, Edward G., Burkhart, Keith, Strauss, David G., Stavitskaya, Lidiya, Lodola, Ales

Journal:

Year:

2020

File:

PDF, 1.08 MB

2020

12

Validation and characterization of five distinct novel inhibitors of human cytomegalovirus

Kapoor, Arun, Ghosh, Ayan Kumar, Forman, Michael, Hu, Xin, Ye, Wenjuan, Southall, Noel, Marugan, Juan J, Keyes, Robert F, Smith, Brian C, Meyers, David J., Ferrer, Marc, Arav-Boger, Ravit

Journal:

Journal of Medicinal Chemistry

Year:

2020

Language:

english

File:

PDF, 1.20 MB

english, 2020

13

ChemInform Abstract: A View of the Hydrophobic Effect

Noel T. Southall, Ken A. Dill, A. D. J. Haymet

Journal:

Year:

2002

File:

PDF, 24 KB

2002

14

A new resorufin-based α-glucosidase assay for high-throughput screening

Omid Motabar, Zhen-Dan Shi, Ehud Goldin, Ke Liu, Noel Southall, Ellen Sidransky, Christopher P. Austin, Gary L. Griffiths, Wei Zheng

Journal:

Analytical Biochemistry

Year:

2009

Language:

english

File:

PDF, 408 KB

english, 2009

15

A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel

Steven A. Titus, Daniel Beacham, Sampada A. Shahane, Noel Southall, Menghang Xia, Ruili Huang, Elizabeth Hooten, Yong Zhao, Louie Shou, Christopher P. Austin, Wei Zheng

Journal:

Analytical Biochemistry

Year:

2009

Language:

english

File:

PDF, 546 KB

english, 2009

16

Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death

Ping Jun Zhu, John P. Hobson, Noel Southall, Cunping Qiu, Craig J. Thomas, Jiamo Lu, James Inglese, Wei Zheng, Stephen H. Leppla, Thomas H. Bugge, Christopher P. Austin, Shihui Liu

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 913 KB

english, 2009

17

Identification of a potent new chemotype for the selective inhibition of PDE4

Amanda P. Skoumbourdis, Ruili Huang, Noel Southall, William Leister, Vicky Guo, Ming-Hsuang Cho, James Inglese, Marshall Nirenberg, Christopher P. Austin, Menghang Xia, Craig J. Thomas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 421 KB

english, 2008

18

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

Jian-kang Jiang, Matthew B. Boxer, Matthew G. Vander Heiden, Min Shen, Amanda P. Skoumbourdis, Noel Southall, Henrike Veith, William Leister, Christopher P. Austin, Hee Won Park, James Inglese, Lewis

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 855 KB

english, 2010

19

Evaluation of 2-thioxo-2,3,5,6,7,8-hexahydropyrimido[4,5-d]pyrimidin-4(1H)-one analogues as GAA activators

Juan J. Marugan, Wei Zheng, Omid Motabar, Noel Southall, Ehud Goldin, Ellen Sidransky, Ronald A. Aungst, Ke Liu, Subir Kumar Sadhukhan, Christopher P. Austin

Journal:

European Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.81 MB

english, 2010

20

Potential of mean force between two hydrophobic solutes in water

Noel T. Southall, Ken A. Dill

Journal:

Biophysical Chemistry

Year:

2002

Language:

english

File:

PDF, 1.29 MB

english, 2002

21

Synthesis and characterization of a new fluorogenic substrate for alpha-galactosidase

Zhen-Dan Shi, Omid Motabar, Ehud Goldin, Ke Liu, Noel Southall, Ellen Sidransky, Christopher P. Austin, Gary L. Griffiths, Wei Zheng

Journal:

Analytical and Bioanalytical Chemistry

Year:

2009

Language:

english

File:

PDF, 410 KB

english, 2009

22

Two high-throughput screening assays for aberrant RNA–protein interactions in myotonic dystrophy type 1

Catherine Z. Chen, Krzysztof Sobczak, Jason Hoskins, Noel Southall, Juan J. Marugan, Wei Zheng, Charles A. Thornton, Christopher P. Austin

Journal:

Analytical and Bioanalytical Chemistry

Year:

2012

Language:

english

File:

PDF, 530 KB

english, 2012

23

Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries

Veith, Henrike, Southall, Noel, Huang, Ruili, James, Tim, Fayne, Darren, Artemenko, Natalia, Shen, Min, Inglese, James, Austin, Christopher P, Lloyd, David G

Journal:

Nature Biotechnology

Year:

2009

Language:

english

File:

PDF, 588 KB

english, 2009

24

The Mechanism of Hydrophobic Solvation Depends on Solute Radius

Southall, Noel T., Dill, Ken A.

Journal:

Journal of Physical Chemistry B

Year:

2000

Language:

english

File:

PDF, 181 KB

english, 2000

25

Evaluation of Substituted N,N′-Diarylsulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase

Shen, Min, Skoumbourdis, Amanda P., Southall, Noel, Veith, Henrike, Leister, William, Austin, Christopher P., Park, Hee Won, Boxer, Matthew B., Jiang, Jian-kang, Vander Heiden, Matthew G.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.03 MB

english, 2010

26

Discovery, Structure–Activity Relationship, and Biological Evaluation of Noninhibitory Small Molecule Chaperones of Glucocerebrosidase

Patnaik, Samarjit, Zheng, Wei, Choi, Jae H., Motabar, Omid, Southall, Noel, Westbroek, Wendy, Lea, Wendy A., Velayati, Arash, Goldin, Ehud, Sidransky, Ellen, Leister, William, Marugan, Juan J.

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 3.38 MB

english, 2012

27

A high-throughput sphingomyelinase assay using natural substrate

Xu, Miao, Liu, Ke, Southall, Noel, Marugan, Juan J., Remaley, Alan T., Zheng, Wei

Journal:

Analytical and Bioanalytical Chemistry

Year:

2012

Language:

english

File:

PDF, 318 KB

english, 2012

28

Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels

Menghang Xia, Sampada A. Shahane, Ruili Huang, Steven A. Titus, Enoch Shum, Yong Zhao, Noel Southall, Wei Zheng, Kristine L. Witt, Raymond R. Tice, Christopher P. Austin

Journal:

Toxicology and Applied Pharmacology

Year:

2011

Language:

english

File:

PDF, 728 KB

english, 2011

29

Discovery of a Novel Noniminosugar Acid α Glucosidase Chaperone Series

Xiao, Jingbo, Westbroek, Wendy, Motabar, Omid, Lea, Wendy A., Hu, Xin, Velayati, Arash, Zheng, Wei, Southall, Noel, Gustafson, Ann Marie, Goldin, Ehud, Sidransky, Ellen, Liu, Ke, Simeonov, Anton, Tama

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.84 MB

english, 2012

30

Characterization of Diversity in Toxicity Mechanism Using in Vitro Cytotoxicity Assays in Quantitative High Throughput Screening

Huang, Ruili, Southall, Noel, Cho, Ming-Hsuang, Xia, Menghang, Inglese, James, Austin, Christopher P.

Journal:

Chemical Research in Toxicology

Year:

2008

Language:

english

File:

PDF, 1.58 MB

english, 2008

31

Evaluation of Quinazoline Analogues as Glucocerebrosidase Inhibitors with Chaperone Activity

Marugan, Juan J., Zheng, Wei, Motabar, Omid, Southall, Noel, Goldin, Ehud, Westbroek, Wendy, Stubblefield, Barbara K., Sidransky, Ellen, Aungst, Ronald A., Lea, Wendy A.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.61 MB

english, 2011

32

Characterization of Chemical Libraries for Luciferase Inhibitory Activity

Auld, Douglas S., Southall, Noel T., Jadhav, Ajit, Johnson, Ronald L., Diller, David J., Simeonov, Anton, Austin, Christopher P., Inglese, James

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 548 KB

english, 2008

33

155. High Throughput screen for identifying small molecule modulators of alpha-glucosidase for the potential treatment of Pompe disease

Wei Zheng, Omid Motabar, Ke Liu, Ehud Goldin, Noel Southall, Juan Marugan, Christopher Austin, Ellen Sidransky

Journal:

Molecular Genetics and Metabolism

Year:

2009

Language:

english

File:

PDF, 41 KB

english, 2009

34

Selective Modulation of Gq/Gs pathways by Naphtho Pyrano Pyrimidines As Antagonists of the Neuropeptide S Receptor

McCoy, Joshua G., Marugan, Juan J., Liu, Ke, Zheng, Wei, Southall, Noel, Huang, Wenwei, Heilig, Markus, Austin, Christopher P.

Journal:

ACS Chemical Neuroscience

Year:

2010

Language:

english

File:

PDF, 2.05 MB

english, 2010

35

Inhibitors of the Yersinia protein tyrosine phosphatase through high throughput and virtual screening approaches

Hu, Xin, Vujanac, Milos, Southall, Noel, Erec Stebbins, C.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.79 MB

english, 2013

36

Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules

Childs-Disney, Jessica L., Stepniak-Konieczna, Ewa, Tran, Tuan, Yildirim, Ilyas, Park, HaJeung, Chen, Catherine Z., Hoskins, Jason, Southall, Noel, Marugan, Juan J., Patnaik, Samarjit, Zheng, Wei, Aus

Journal:

Nature Communications

Year:

2013

Language:

english

File:

PDF, 1.36 MB

english, 2013

37

Discovery, Synthesis, and Biological Evaluation of Novel SMN Protein Modulators

Xiao, Jingbo, Marugan, Juan J., Zheng, Wei, Titus, Steve, Southall, Noel, Cherry, Jonathan J., Evans, Matthew, Androphy, Elliot J., Austin, Christopher P.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 4.14 MB

english, 2011

38

Structure–Activity Relationship of Imidazopyridinium Analogues as Antagonists of Neuropeptide S Receptor

Patnaik, Samarjit, Marugan, Juan J., Liu, Ke, Zheng, Wei, Southall, Noel, Dehdashti, Seameen J., Thorsell, Annika, Heilig, Markus, Bell, Lauren, Zook, Michelle, Eskay, Bob, Brimacombe, Kyle R., Austin

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.39 MB

english, 2013

39

Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1

Xiao, Jingbo, Huang, Zaohua, Chen, Catherine Z., Agoulnik, Irina U., Southall, Noel, Hu, Xin, Jones, Raisa E., Ferrer, Marc, Zheng, Wei, Agoulnik, Alexander I., Marugan, Juan J.

Journal:

Nature Communications

Year:

2013

Language:

english

File:

PDF, 534 KB

english, 2013

40

A high-throughput screening assay using Krabbe disease patient cells

Ribbens, Jameson, Whiteley, Grace, Furuya, Hirokazu, Southall, Noel, Hu, Xin, Marugan, Juan, Ferrer, Marc, Maegawa, Gustavo H.B.

Journal:

Analytical Biochemistry

Year:

2013

Language:

english

File:

PDF, 1.17 MB

english, 2013

41

A high-throughput screening assay using Krabbe disease patient cells

Maegawa, Gustavo, Ribbens, Jameson, Whiteley, Grace, Furuya, Hirokazu, Southall, Noel, Hu, Xin, Marugan, Juan, Ferrer, Marc, Maegawa, Gustavo

Journal:

Molecular Genetics and Metabolism

Year:

2013

Language:

english

File:

PDF, 60 KB

english, 2013

42

Targeting IRAK1 as a Therapeutic Approach for Myelodysplastic Syndrome

Rhyasen, Garrett W., Bolanos, Lyndsey, Fang, Jing, Jerez, Andres, Wunderlich, Mark, Rigolino, Carmela, Mathews, Lesley, Ferrer, Marc, Southall, Noel, Guha, Rajarshi, Keller, Jonathan, Thomas, Craig, B

Journal:

Year:

2013

Language:

english

File:

PDF, 2.76 MB

english, 2013

43

Structural insight into exosite binding and discovery of novel exosite inhibitors of botulinum neurotoxin serotype A through in silico screening

Hu, Xin, Legler, Patricia M., Southall, Noel, Maloney, David J., Simeonov, Anton, Jadhav, Ajit

Journal:

Journal of Computer-Aided Molecular Design

Year:

2014

Language:

english

File:

PDF, 2.51 MB

english, 2014

44

Response to “Comment on ‘The Mechanism of Hydrophobic Solvation Depends on Solute Radius', J. Phys. Chem. B 2000, 104 , 1326”

Southall, Noel T., Dill, Ken A.

Journal:

Journal of Physical Chemistry B

Year:

2001

Language:

english

File:

PDF, 25 KB

english, 2001

45

Kinase Patent Space Visualization Using Chemical Replacements

Southall, Noel T., Ajay,

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 232 KB

english, 2006

46

A View of the Hydrophobic Effect

Southall, Noel T., Dill, Ken A., Haymet, A. D. J.

Journal:

Journal of Physical Chemistry B

Year:

2002

File:

PDF, 5 KB

2002

47

A quantitative high-throughput screen for modulators of IL-6 signaling: a model for interrogating biological networks using chemical libraries

Johnson, Ronald L., Huang, Ruili, Jadhav, Ajit, Southall, Noel, Wichterman, Jennifer, MacArthur, Ryan, Xia, Menghang, Bi, Kun, Printen, John, Austin, Christopher P., Inglese, James

Journal:

Molecular BioSystems

Year:

2009

Language:

english

File:

PDF, 2.44 MB

english, 2009

48

The synthesis and evaluation of dihydroquinazolin-4-ones and quinazolin-4-ones as thyroid stimulating hormone receptor agonists

Englund, Erika E., Neumann, Susanne, Eliseeva, Elena, McCoy, Joshua G., Titus, Steven, Zheng, Wei, Southall, Noel, Shinn, Paul, Leister, William, Thomas, Craig J., Inglese, James, Austin, Christopher

Journal:

Year:

2011

Language:

english

File:

PDF, 132 KB

english, 2011

49

A Multiplex Calcium Assay for Identification of GPCR Agonists and Antagonists

Liu, Ke, Southall, Noel, Titus, Steve A., Inglese, James, Eskay, Robert L., Shinn, Paul, Austin, Christopher P., Heilig, Markus A., Zheng, Wei

Journal:

Assay and Drug Development Technologies

Year:

2010

Language:

english

File:

PDF, 2.83 MB

english, 2010

50

A Cell-Based Assay for I κ B α Stabilization Using A Two-Color Dual Luciferase-Based Sensor

Davis, R. Eric, Zhang, Ya-Qin, Southall, Noel, Staudt, Louis M., Austin, Christopher P., Inglese, James, Auld, Douglas S.

Journal:

Assay and Drug Development Technologies

Year:

2007

Language:

english

File:

PDF, 5.26 MB

english, 2007